ISSN 1662-4009 (online)

ey0018.9-3 | Childhood cancer and thyroid disease | ESPEYB18

9.3. Presentation and outcome of subsequent thyroid cancer among childhood cancer survivors compared to sporadic thyroid cancer: a matched national study

SC Clement , CA Lebbink , MS Klein Hesselink , JC Teepen , TP Links , CM Ronckers , HM van Santen

Eur J Endocrinol. 2020; 183: 169–180. https://pubmed.ncbi.nlm.nih.gov/32449692/This retrospective study analyzed subsequent differentiated thyroid cancer (DTC) in in a group of CCS (n=31) matched with patients affected by sporadic DTC (n=93) to compare clinical presentation and outcomes. CCS with subsequent DTC were identified by two source populations: the DCOG-LATER cohort o...

ey0016.11-14 | Treatment of Severe Obesity: Next Steps | ESPEYB16

11.14. Pathophysiology and individualized treatment of hypothalamic obesity following craniopharyngioma and other suprasellar tumors: a systematic review

L van Iersel , KE Brokke , RAH Adan , LCM Bulthuis , ELT van den Akker , HM van Santen

To read the full abstract: Endocr Rev. 2019;40(1):193–235This paper combines a comprehensive review of current knowledge on pathophysiologic mechanisms contributing to hypothalamic obesity in craniopharyngioma patients with a systematic literature review of intervention studies for weight management in this patient population. Findings of both reviews are merged into evidence-...

ey0020.1-13 | Pediatric Thyroid Cancer | ESPEYB20

1.13. 2022 European Thyroid Association Guidelines for the management of pediatric thyroid nodules and differentiated thyroid carcinoma

CA Lebbink , TP Links , A Czarniecka , RP Dias , R Elisei , L Izatt , H Krude , K Lorenz , M Luster , K Newbold , A Piccardo , M Sobrinho-Simoes , T Takano , AS Paul van Trotsenburg , FA Verburg , HM van Santen

Brief summary: American Thyroid Association Guidelines for management of children with thyroid nodules and differentiated thyroid cancer were published in 2015 (1). Now Lebbink et al. published management guidelines from the European Thyroid Association.Pediatric differentiated thyroid carcinoma is rare. For many aspects of the disease (diagnosis, treatment, follow-up) clear evidence from randomized controlled trials are therefore missing. The p...

ey0020.7-8 | Bone Health in Childhood Cancer Survivors | ESPEYB20

7.8. Risk and determinants of low and very low bone mineral density and fractures in a national cohort of Dutch adult childhood cancer survivors (DCCSS-LATER): a cross-sectional study

JE van Atteveld , DTC de Winter , VG Pluimakers , M Fiocco , RAJ Nievelstein , MGG Hobbelink , ACH de Vries , JJ Loonen , E van Dulmen-den Broeder , HJ van der Pal , SMF Pluijm , LCM Kremer , CM Ronckers , M van der Heiden-van der Loo , AB Versluijs , M Louwerens , D Bresters , HM van Santen , DS Olsson , I Hoefer , SAA van den Berg , J den Hartogh , WJE Tissing , SJCMM Neggers , MM van den Heuvel-Eibrink , Dutch LATER study group

Brief summary: This Dutch cross-sectional study aimed to assess risk factors for impaired bone mineral density (BMD) and fractures (particularly vertebral fractures) in adult survivors of childhood cancer. The relationships between low BMD (Z-score ≤–1), very low BMD (Z-score ≤–2), fractures, vertebral fractures, and demographic, treatment-related, endocrine, and lifestyle-related factors was analyzed by logistic regression.<p class=...

ey0020.7-15 | Long-Term Surveillance for Endocrine Complications in Childhood Cancer Survivors | ESPEYB20

7.15. Frailty and sarcopenia within the earliest national Dutch childhood cancer survivor cohort (DCCSS-LATER): a cross-sectional study

JE van Atteveld , DTC de Winter , VG Pluimakers , M Fiocco , RAJ Nievelstein , MGG Hobbelink , LCM Kremer , MA Grootenhuis , H Maurice-Stam , WJE Tissing , ACH de Vries , JJ Loonen , E van Dulmen-den Broeder , HJH van der Pal , SMF Pluijm , M van der Heiden-van der Loo , AB Versluijs , M Louwerens , D Bresters , HM van Santen , I Hoefer , SAA van den Berg , J den Hartogh , JHJ Hoeijmakers , SJCMM Neggers , MM van den Heuvel-Eibrink , Dutch LATER study group

Brief summary: This cross-sectional study explored the risk factors for pre-frailty, frailty, and sarcopenia in a cohort of Dutch childhood cancer survivors diagnosed between 1963 and 2001.Frailty was defined as the presence of at least two (pre-frailty) or three (frailty) of the following criteria: low appendicular lean mass (low percentage of lean tissue in the limbs assessed by dual-energy X-ray absorptiometry, DXA), low muscle strength (measured with...

ey0019.9-1 | Cancer treatment and growth hormone therapy: a consensus | ESPEYB19

9.1. Safety of growth hormone replacement in survivors of cancer and intracranial and pituitary tumours: a consensus statement

MCS Boguszewski , CL Boguszewski , W Chemaitilly , LE Cohen , J Gebauer , C Higham , AR Hoffman , M Polak , KCJ Yuen , N Alos , Z Antal , M Bidlingmaier , BMK Biller , G Brabant , CSY Choong , S Cianfarani , PE Clayton , R Coutant , AA Cardoso-Demartini , A Fernandez , A Grimberg , K Guðmundsson , J Guevara-Aguirre , KKY Ho , R Horikawa , AM Isidori , JOL Jorgensen , P Kamenicky , N Karavitaki , JJ Kopchick , M Lodish , X Luo , AI McCormack , L Meacham , S Melmed , Moab S Mostoufi , HL Muller , SJCMM Neggers , Oliveira MH Aguiar , K Ozono , PA Pennisi , V Popovic , S Radovick , L Savendahl , P Touraine , HM van Santen , G Johannsson

n.karavitaki@bham.ac.uk Eur J Endocrinol. 2022; 186: P35-P52. PMID: 35319491.Brief Summary: An international panel of experts produced this consensus statement after critical review of the existing evidence on the safety of GH replacement in cancer and intracranial tumour survivors and in patients with increased cancer risk. Current evidence does not support an association betwe...

ey0020.7-14 | Long-Term Surveillance for Endocrine Complications in Childhood Cancer Survivors | ESPEYB20

7.14. Hypothalamic-pituitary and other endocrine surveillance among childhood cancer survivors

L van Iersel , RL Mulder , C Denzer , LE Cohen , HA Spoudeas , LR Meacham , E Sugden , AYN Schouten-van Meeteren , EW Hoving , RJ Packer , GT Armstrong , S Mostoufi-Moab , AM Stades , D van Vuurden , GO Janssens , C Thomas-Teinturier , RD Murray , N Di Iorgi , SJCMM Neggers , J Thompson , AA Toogood , H Gleeson , C Follin , E Bardi , L Torno , B Patterson , V Morsellino , G Sommer , SC Clement , D Srivastava , CE Kiserud , A Fernandez , K Scheinemann , S Raman , KCJ Yuen , WH Wallace , LS Constine , R Skinner , MM Hudson , LCM Kremer , W Chemaitilly , HM van Santen

Brief summary: In this extensive and updated review, the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) report expert consensus-based guidelines that harmonize recommendations for surveillance of endocrine disorders in childhood cancer survivors.This interdisciplinary panel of 42 international experts formulated new surveillance recommendations for hypothalamic–pituitary (HP) dysfunction. Existing IGHG surveillan...